منابع مشابه
β-Adrenergic Receptor Signaling in Prostate Cancer
Enhanced sympathetic signaling, often associated with obesity and chronic stress, is increasingly acknowledged as a contributor to cancer aggressiveness. In prostate cancer, intact sympathetic nerves are critical for tumor formation, and sympathectomy induces apoptosis and blocks tumor growth. Perineural invasion, involving enrichment of intra-prostatic nerves, is frequently observed in prostat...
متن کاملClinical significance of estrogen receptor β in breast and prostate cancer from biological aspects
Breast and prostate cancers are among the most common of all cancers. They are referred to as hormone-dependent cancers, because estrogen and androgen are involved in their development and growth. The effects of these hormones are mediated by their respective receptors, estrogen receptor (ER) α and androgen receptor. Around 18 years ago, a second ER, ERβ, which has a very similar structure to E...
متن کاملProspects of estrogen receptor β activation in the treatment of castration-resistant prostate cancer
Advanced prostate cancer can develop into castration-resistant prostate cancer (CRPC). This process is mediated either by intratumoral ligand synthesis or by mutations or aberrations of the androgen receptor (AR) or its cofactors. To date, no curative therapy for CRPC is available, as AR-targeted therapies eventually result in the development of resistance. The human prostate cancer cell line V...
متن کاملDioscin induces prostate cancer cell apoptosis through activation of estrogen receptor-β
Recent researches have shown that estrogen receptor-β (ERβ) activator may be a potent anticancer agent for prostate cancer (PCa), and our previous study also indicated that dioscin can upregulate the expression of ERβ in MC3T3-E1 cell. In the present work, the activity and mechanism of dioscin, a natural product, against PCa were investigated. The results showed that dioscin markedly inhibited ...
متن کاملRoles of ARA55 and ARA55-estrogen receptor β signaling pathway on the prostate cancer
Objective: To investigate the effect of ARA55 over-expression on the prostate cancer proliferation, aggression and apoptosis; to investigate whether ARA55 can regulate the expression of TGF-β or Smad7 in prostate cancer cells, and its relationship with estrogen receptor. Methods: The expression of ARA55, estrogen receptor α (ERα), ERβ, TGF-β and Smad7 was detected in human prostate cancer tissu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2001
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)61666-5